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AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.
The Senior Scientist I will play a key role in the developing downstream purification process development for various modalities such as mAbs, ADCs, bispecifics, gene therapy, etc. Ideal candidate will conceive and implement novel experimental and/or modeling approaches to answer scientific questions. The mission of this team is to address challenging problems in biologics development areas by working collaboratively and cross-functionally by developing appropriate tools and technologies to enable right at first pass scale-up and technology transfer of various biologics modalities drug substance processes.
Responsibilities:
·Develop recovery and purification process that utilizes clarification, chromatography, and membrane filtration technologies for monoclonal antibodies, bispecifics and antibody drug conjugates (ADC). Provide deeper understanding of process performance using appropriate experimental and modeling tools.
·Design and execute process development and characterization activities, impurity and viral clearance studies. Highly independent and productive in performing laboratory research and/or development, requiring only minimal direction from or interaction with supervisor.
·Responsible for technology transfer to pilot lab and cGMP manufacturing facilities, troubleshooting and investigation activities. Provide person-in-plant support for pilot and/or cGMP manufacturing campaigns.
·Leveraging state-of-art data science and data engineering technology to develop digital tools, database and visualization platform.
·Proactively seek opportunities to come up with innovative modeling, machine learning and AI solutions to address business challenges and accelerate process development.
·Exhibit a strong motivation to implement and advance various innovative technologies (such as continuous manufacturing, automation, and/or novel resins and filters) in relevant areas across AbbVie.
·Routinely demonstrate scientific initiative and creativity in research or development activities. Capable of being a primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
·Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.
·Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD with 0-2 years experience necessary.
·Education background in chemical engineering, biomedical engineering, biochemistry, biochemical engineering, or biotechnology is preferred.
·Experience in areas of data engineer, data science, machine learning, process optimization, and data-driven/mechanistic modeling is strongly preferred.
·Experience in areas of purification process development is strongly preferred.
·Experience in areas of continuous manufacturing is preferred.
·Demonstrate excellent communication skills and specifically illustrate strong oral and written technical communications.
·Seamlessly present research outcomes to multifunctional teams.
·Play a strong team player in a cross functional collaborative environment thriving for world class excellence and maintains strong working relationships with internal, global, and external collaborators.
·Demonstrated problem-solving skills and capability to overcome complex issues.
·Demonstrated success in coordinating and executing important projects to achieve business goals.
·Must have a “results-oriented” work ethic and a positive “can-do” attitude with a strong sense of urgency and self-motivated desire to achieve.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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