Overview

The Oncology Research group at Alnylam is seeking a highly motivated Associate Scientist II to join our growing interdisciplinary team aimed at developing RNAi therapeutics against cancer. The successful candidate will be technically skilled in synthetic organic chemistry laboratory techniques and contribute to the synthesis, purification, and characterization of oligonucleotide conjugates to support various oncology drug discovery projects. The candidate must be motivated, have strong interpersonal and communication skills, and be able to work on a highly collaborative team.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Perform synthesis, purification and characterization of siRNA conjugates including small molecule, peptide, or protein conjugates and contributes to the development of new synthetic approaches toward these modalities.
• Improve upon or develop new methods to streamline workflows for generating different siRNA delivery modalities.
• Effectively troubleshoot synthetic and process challenges and independently come up with solutions.
• Manage sample inventory and keeps detailed records in an electronic notebook.
• Analyze and interpret data and communicates results to the team.
• Collaborate with team members throughout the organization to progress drug discovery efforts, contributing to a dynamic, exciting culture that embraces teamwork, innovation, and transparency.

Qualifications

• Bachelor’s or Master’s degree in Chemistry, Chemical Biology, or a related field.
• 0-4 years of work experience, preferably in an industrial setting.
• Proficiency in synthetic organic chemistry lab techniques and instrumentation such as NMR, HPLC, LC-MS, UV-Vis spectrometry, etc. is required.
• Experience in biorthogonal chemistry and good understanding of the challenges in working with various bioconjugate formats preferred.
• Experience in developing new chromatographic methods (IEX/RP HPLC, SEC, LC-MS) is a plus.
• Passionate about scientific discovery and eager to learn new skills and contribute to the success of the organization.
• Strong organizational, communication, and critical thinking skills.
• Excellent communicator, execution-focused and team-oriented.
• Good record keeping abilities to adequately document protocols and experimental data.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.