Associate Principal Scientist in Process Analytical Technology

AstraZeneca

AstraZeneca

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IT
Gothenburg, Sweden
Posted on Saturday, February 10, 2024

Are you ready to make a meaningful impact on people's lives with life-changing medicines? We are currently looking for an Associate Principal Scientist in Product and Process Control to strengthen our capabilities in the development and implementation of enhanced control strategies to our late phase portfolio. Join our Operations team in Gothenburg and be part of a team where everyone feels a personal connection to the people we impact.

At AstraZeneca, our Operations team has a big ambition: to deliver more medicines to patients, quicker and more affordably. We are driven by our commitment to deliver accelerated growth for AstraZeneca and to make people's lives better.

In Pharmaceutical Technology and Development (PT&D), within Operations, we are the bridge between brilliant science and innovative medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

At Oral Product Development (OPD) in Gothenburg, a sub-division of PT&D, we focus on the fields of Oral Controlled Release Drug products and Immediate Release Drug Products. You will join a vibrant team that is working on the next generation of medicines and play a key role in the development of new medicinal product.

What you’ll do

As an Associate Principal Scientist, you will play a crucial role in designing, developing, and delivering high-quality enhanced control strategies by applying your expert knowledge in the areas of PAT, Chemometrics, and advanced process monitoring and control tools. You will collaborate with cross-functional teams, contribute to regulatory documentation, and lead digital projects implementing innovative monitoring and control tools to our continuous manufacturing platforms. You will also take part in the validation and technical transfer of models and/ or PAT tools supporting product control strategies across Operations. You will also bring a future focussed, innovative mindset to deliver further digitally oriented approaches, data science, predictive modelling and simulation, and artificial intelligence.

Essential for the role:

  • BSc, MSc or equivalent in a relevant field (chemistry, pharmacy, engineering etc.) with experience in the use of PAT in the Pharmaceutical or Chemical industries and/or postgraduate experience in Academia with a PAT industrial focus.

  • A strong understanding of key process analytical technologies especially NIR, Raman and Microwave Spectroscopy

  • Demonstrated expertise in PAT method development, implementation, and use of multi-variate data analysis/ Chemometrics (MVDA, PCA, PLS) in common software platforms (SIMCA, Python, PLS Toolbox etc.)

  • Broad knowledge of pharmaceutical process equipment/technology for continuous processes

  • Ability to document and present your work concisely and comprehensibly

  • Strong collaboration, communication, and leadership skills

  • An understanding of the principles and management of Safety, Health & Environment (SHE)

Desirable for the role:

  • Demonstrated experience of ensuring compliance with operational requirements (GMP, GAMP, Process Safety, Data integrity, Change Control)

  • Industrial experience developing control strategies for pharmaceutical commercial manufacturing processes

  • Experience of advanced process control and model predictive control (artificial intelligence and machine Learning) applied to continuous manufacturing and technology transfer

  • Experience with digital tools supporting enhanced control strategies (DCS, PAT management system, APC, Multivariate monitoring platform)

  • Demonstrated experience of regulatory authoring of models/control strategies for pharmaceutical manufacturing processes

Why AstraZeneca?

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people's lives better. It pushes us to keep building on our foundations and progressing as we turn our ever-growing and increasingly complex pipeline from molecule to medicine. Be part of evolving how we work with Lean, innovative science, digitalisation, and sustainable practices. We're always working towards our ambition to deliver accelerated growth for AstraZeneca and to make people's lives better. By responding to larger patient populations and our diverse pipeline, we are driving commercial viability and rapidly scaling delivery.

So, what’s next?

Don't miss this opportunity to make a meaningful impact on people's lives – apply now!

Welcome with your application no later than February 25th.

Date Posted

09-feb.-2024

Closing Date

25-feb.-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

This job is no longer accepting applications

See open jobs at AstraZeneca.