Principal Scientist - Metabolism Bioscience Research, CVRM



Cambridge, UK
Posted on Tuesday, June 11, 2024

Principal Scientist – Metabolism Bioscience Research, CVRM

Location: Cambridge, UK

Career Level F

Are you an expert in in vitro pharmacology within the metabolic disease research area? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic (CVRM) diseases!

Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a high calibre Principal Scientist to join the in vitro metabolism bioscience team within Research and Early Development CVRM. The position is placed at AstraZeneca’s Global HQ R&D site in Cambridge, UK.

CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM Metabolism Bioscience department has a dynamic environment that fosters collaboration and innovation. We are a team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients suffering from diabetes, obesity, dyslipidaemia, and liver diseases.

What you’ll do:

This is a key scientific leadership position where the successful candidate can excel from both the lab bench and through project leadership. You will develop and lead scientific and technical capabilities required for progressing drug discovery projects within the metabolic disease area and influence the departmental strategy. You will lead the generation of key experimental data supporting multi-disciplinary project teams across Cambridge, Gothenburg and Gaithersburg.

Role Profile:

  • You will be an expert in the metabolic disease research area and will play an active role in the prosecution of a rapidly moving portfolio of drug projects
  • You will engage in developing the groups capabilities and projects through highly innovative scientific research aimed at bringing new treatment options to patients
  • You will work with the leadership team to contribute to the research strategy evolution and direction in Metabolism Bioscience department.
  • Act as a champion for novel approaches for drug discovery, promoting scientific debate and innovation within CVRM Research through inspiring personal leadership and mentorship.
  • Recognised as an expert in own field; working on difficult drug projects to solve scientific complex questions to provide solutions that are highly innovative
  • You will play a leading role in the selection and validation of research targets through to early clinical development for a broad range of therapeutics modalities. Reporting to the Senior Director of Metabolism Bioscience, based in Cambridge, UK
  • You will be an expert in new in vitro models and methodologies with an enthusiasm for laboratory work and scientific curiosity.
  • You will act as bioscience lead and project leader on discovery projects to conduct, plan and lead highly complex scientific projects with internal multidisciplinary teams and collaborators within and outside the organisation.
  • Raise the scientific profile of CVRM both within AstraZeneca and externally through publications, presentations and leading collaborations.

Essential for the role

  • PhD and postdoctoral experience in life sciences or equivalent relevant industry experience.
  • 5+ years’ experience in the pharmaceutical / biotech industry and drug discovery
  • Expert scientific knowledge in metabolic disease research areas such as diabetes, obesity, dyslipidaemia or MASH.
  • Proven expertise in in vitro pharmacology, molecular and cellular biology with ability to direct laboratory based research
  • Evidence of scientific leadership recognised by publication record and enthusiasm to maintain a high external scientific profile through publication and conference presentations.
  • Proven ability to manage complex projects, collaborations and partnerships

Desirable for the role

  • Experience of writing pharmacology section of regulatory submissions
  • Significant experience of numerous in vitro and ex vivo technologies for assessing signalling endpoints for multiple target classes.
  • Strong evidence of ability in leading several simultaneous projects/tasks
  • Extensive experience working with a network of research experts in the metabolism field.

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

To be considered for this exciting opportunity, please complete the full application at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.

Welcome with your application no later than 30th June

Where can I find out more?

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted


Closing Date

30-Jun-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.