Position Summary

AstraZeneca is looking for you to join our personalized (neo)antigen-specific T cell receptor (TCR) discovery research team as a Cellular Immunology Associate Scientist. You will assume responsibilities for conducting experimental work aiming to develop and improve neoantigen-specific TCR discovery technology. The position is based in Amsterdam, The Netherlands, and you will report to the personalized TCR discovery team lead.

If interested please submit a motivation letter with your resume.

Responsibilities

• Perform cell-based TCR discovery and characterization studies under the supervision of senior research staff. Involved techniques include magnetic bead-based isolation of human immune cell lines (T cells, B cells, and others), phenotypic and functional evaluation of immune cells by flow cytometry and microplate-based readouts, genetic modification of primary immune cells and cell lines using retro-/lenti-viruses and gene editing tools (e.g. CRISPR-Cas9).

• Support assay development.

• Keep track of relevant technology developments in literature.

• Document experimental results in electronic laboratory journal and databases.

• Present obtained results in internal work discussions.

• Complete tasks related to laboratory operations under guidance of the Lab-manager.

• Other responsibilities and special projects as assigned.

Education and Experience

• Bachelor or Master degree in Biomedical Sciences or a related field.

• Knowledge on aseptic cell culture techniques is required.

• Candidates with a background in immunology and first-hand experience with flow cytometry are preferred.

• Additional training in the area of B and T cell culture, genetic manipulation of cells using retrovirus, lentivirus or gene editing tools (e.g. CRISPR-Cas9), molecular biology (plasmid design/construction) are a plus.

• Excellent organizational skills, a strong sense of urgency and responsibility with regards to work duties and the ability to deliver results based on challenging timelines.

• Strong verbal and written communication skills in English.

• Comfortable in a fast-paced growing company environment and able to adjust work planning based upon changing priorities.

• We are looking for a person who is a self-motivated team player with strong interpersonal skills and will lead by example.

• Experience with Genetically Modified Organisms (GMO) work is preferred.

• You must be authorized to work in The Netherlands.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.