Company Overview:

Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Position Overview:

Beam is seeking a scientist with expertise in formulation and product development. The candidate will work on formulation and scale-up of lipid nanoparticles (LNPs) targeting different organs and cell types. They will work as part of a team to develop drug products with the goal of bringing in vivo base editing to patients.

We are looking for an ambitious candidate who wants to grow within the LNP development (process and formulation) group. This candidate will help shape the LNP platform and would grow with the aspirations of the organization as we advance into later stages of development.

Responsibilities:

• Responsible for formulation design, development, characterization, and technology transfer to enable development of Beam sterile drug products.
• Accountable as an individual contributor to support formulation development as well as providing necessary guidance and support of drug product control strategy for drug candidates across all stages of development.
• Execute process development studies and independently design, perform, analyze, and document at-scale and/or scaled-down experiments.
• Design and execute experiments to enable a robust formulation and reproducible process for manufacture of clinical trial materials. Characterize different unit operations for the manufacturing of DP to understand process robustness.
• Provide support with tech transfer activities for manufacturing of drug product.
• Generate high quality documentation as per Beam SOPs and in support of regulatory filings.
• Communicate scientifically rigorous findings via verbal and written communications, and presentations both internally and externally.

Qualifications:

• PhD or MS in Pharmaceutical Sciences, Chemical engineering, Bioengineering or related field with of drug product and CMC development experience (PhD 4+ years or MS 12+ years).
• Deep understanding of sterile product development. Prior industry research experience especially in nucleic acids and drug delivery is preferred.
• Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests, and proper usage, etc.).
• Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change.
• A successful candidate will have excellent computational, written, and verbal communication skills, strong organizational abilities, and an ability to work with a diverse group of scientists and engineers.
• Ability to work in a hybrid environment with sufficient on-site presence.