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Centre for Genomic Regulation
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
The role
This is a Postdoc position to study the role of X-chromosome inactivation for oocyte development in vitro from mouse embryonic stem cells. In a previous study (Severino et al., EMBO J 2022), we found evidence that X-inactivation is critical for meiotic and oogeneic potential. In this project we want to test this directly and gain insight into the mechanism of this phenomenon. The role would be to bring this ongoing project to completion and publication.
This position will continue the work of Bernhard payer but will be incorporated in the Tissue engineering facility.
About the labs
The Payer lab is interested in elucidating the mechanisms of epigenetic reprogramming during embryogenesis, in pluripotent stem cells and in the germ cell lineage. One particular topic of our interest is the dramatic remodelling of the mammalian X chromosome in females from an inactive to an active state during a process called X-chromosome reactivation. We thereby apply a multitude of in vivo and in vitro model systems, which allows us to interrogate this process and it’s link to pluripotency and germ cell development. The work environment at the CRG consists of a dynamic, international research Institute in Barcelona (Spain) and English is the working language.
The Tissue Engineering Unit is a scientific-technological Core Technology within the Core Technologies Programme. The goal of the Tissue Engineering Unit is to provide CRG, PRBB and external researchers with the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation, induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 gene editing. It was created 8 years ago with the aim of helping the research community in performing Stem Cell and Organoids projects to increase the impact of Stem Cell and Organoid projects and applications. The Unit is constantly setting up new technologies that are emerging in the above fields.
Whom would we like to hire?
Professional experience
Must Have
You have at least 4 years of experience in mouse ESC culture and advanced in vitro differentiation models
You have proven experience in Molecular Biology assays such as PCR and cloning, IF, Microscopy, FACS, single-cell RNA-Seq, DNA-methylation analysis, R-programming
Theoretical Background in Stem cells, Organoids, Epigenetics
Desirable but not required/ Nice to have
Experience with Cut&Run or ChIP-Seq
Education and training
You hold a Phd in the Stem cell and epigenetics field
Languages
You are fluent in English
Technical skills
MS Office, Google Docs, Adobe Illustrator / Photoshop / Affinity designer or equivalent, R
Mammalian Cell culture
Competences
Highly developed organizational skills
The Offer – Working Conditions
Contract duration: 6 months
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
Target start date: 01.01.2025
We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
A motivation letter addressed to Dr Bernhard Payer and Dr Laura Batlle
A complete CV including contact details.
Contact details of two referees.
All applications must be addressed to Dr Bernhard Payer and Dr Laura Batlle and be submitted online through the "Apply" button below.
Selection Process
Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.
Interview: Preselected candidates will be interviewed by the Principal Investigator.
Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application by December 31, 2024.
Proyecto PID2021-123383NB-I00 financiado por MCIN/ AEI / 10.13039/501100011033 / FEDER, UE
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