Full TimeProfessional

Who We Are

EvolveImmune Therapeutics is a next-generation immunotherapy company that is pioneering a new class of precision cancer medicines to transform patient outcomes, compared to current solid tumor therapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable, tissue-localized anti-tumor adaptive immune responses. Our newly-expanded, state-of-the-art 16,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor supports in-house biologic discovery, immunobiology, manufacturing support, and translational activities, which have enabled our rapid pipeline progress. This includes EVOLVE104, our lead solid tumor program which is rapidly advancing toward an IND submission.

The Role

We are seeking a creative and technically strong immunology-focused discovery scientist to join our Immunobiology team. The ideal candidate will have expertise in T cell engager biologic functional assessment, including tumor killing, cytokine production, T cell exhaustion assays, and multiparameter flow cytometry immune cell analysis. Experience in T cell engager discovery, particularly in evaluating CD3 bispecifics or costimulatory biologics, is preferred.

The successful candidate will contribute to the discovery and assessment of novel costimulatory T cell engagers to determine key differentiation design features and supporting mechanisms of action. This includes designing and performing functional assays to prioritize alternative protein designs based on tumor killing potency, cytokine release and immune modulation mechanism of action. Collaboratively design in vivo proof of principle studies to test in vitro-driven hypothesis on molecule prioritization, mechanism of action, lead assessment, and selection of preclinical models to evaluate immune pharmacodynamic and establish in vivo mechanisms of differentiation. They will also work closely with our biotherapeutics and in vivo pharmacology research teams to drive T cell engager platform discoveries to drug development programs. Strong verbal and written communication skills are necessary, as is a proven track record of scientific and project achievements in biopharma.

We are looking for a candidate who thrives in a collaborative, team-oriented environment and is eager to leverage the growth opportunities within a matrixed organization. This is an exceptional opportunity for a scientist passionate about T cell engager platform discovery and driven to translate innovative research into novel therapeutics.

Responsibilities

• Working closely with our protein design and engineering colleagues, design and execute functional ex vivo studies to evaluate protein therapeutics to guide data-driven decisions to evaluate platform innovations.
• Execute experiments focused on functional immune co-culture assays, including mixed lymphocyte reaction, T cell-tumor cell cytotoxicity assays, and other phenotypic assessments of immune cells to identify outcomes associated with protein design features.
• Develop and execute target expression assessment and functional studies with patient samples to delineate differentiation opportunities for emerging and selected lead molecules.
• Work closely with our in vivo pharmacology team to design studies to evaluate the in vivo characteristics such as exploratory molecules and define properties that include the pharmacokinetic profile, early safety readouts, and immune modulation pharmacodynamics in syngeneic and humanized mouse tumor models.
• Keep detailed records of experiments in electronic notebooks, analyze data, prepare and deliver high quality presentations to research team members.

Qualifications

• Master’s degree in Immunology or a related field with 1–3 years of industry experience, or a Bachelor’s degree with 3–5 years of industry experience in immunology or a related field.
• Experience in T cell engager immunotherapies in an academic or drug development setting, including technical experience in assaying tumor killing, cytokine release and immune cell function ex vivo and in vivo.
• Technical expertise in performing multi-color flow cytometry immune cell profiling, Fluorescence Assisted Cell Sorting (FACS) and RNAseq and protein assessment of immune cell subsets.
• Proven ability to participate in biotherapeutic discoveries as demonstrated by a strong publication, patent, and/or drug development record with T cell engager therapies.

EvolveImmune Therapeutics requires all employees to be fully vaccinated against COVID-19. You may seek reasonable accommodation for medical and religious reasons. However, your application is no guarantee that such accommodation will be made available.

EvolveImmune provides competitive compensation and benefits package. EvolveImmune Therapeutics, Inc. is an equal opportunity employer. For more information, please visit https://www.evolveimmune.com/.