Why join us?

Parabilis Medicines (formerly FogPharma) is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis Medicines is headquartered in Cambridge, Mass.

What’s the opportunity?

As the head of drug product development at Parabilis Medicines, you will partner with scientists across the organization to discover and develop the best Helicon^TM peptides and tailor them to fit patients’ needs. We are looking for an enthusiastic and innovative leader to join a multidisciplinary team and help us discover and develop novel inhibitors of undruggable disease targets. Your role will report to the Vice President of Pharmaceutical Development and will be to lead all drug product development at Parabilis. This will require leveraging internal and external capabilities with high flexibility. You will build your own team and help Parabilis develop the best drug development candidates to benefit the patients. Ideal candidates will be energetic and passionate, with a broad knowledge of formulation sciences to influence and guide the best application (oral, parenteral, slow release, etc.) of our investigative drugs.

• Lead all drug product development activities at Parabalis.
• Partner with early discovery through commercialization to discover and implement the best formulation strategy for our Helicon^TM peptides.
• Leverage internal and external capabilities to advance our programs.
• Build an external advisory team of formulation experts to ensure coverage across all aspects of the discipline.
• High visibility advocate and sounding board for formulation opportunities and pragmatic solutions.
• Lead by example and take a hands-on approach to solving our most pressing challenges.

What you’ll need to be successful:

• PhD with a minimum of 10 years of industry experience
• Experience developing oral enabled formulations, parenteral formulations, LNP formulations and/or innovative formulations aimed at improving drug profile.
• Excellent communication, organization, strategic, and cross-functional team skills.
• Experience managing external vendors is a plus.
• Experience with Quality Assurance, Quality systems, and GMP production is a plus.
• Experience with peptides is a plus.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com