Senior Research Scientist I, DMPK

Gilead Sciences

Gilead Sciences

Foster City, CA, USA
Posted on Friday, May 3, 2024

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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Gilead Sciences, Inc. is a research-based biopharmaceutical company headquartered in Foster City, California, that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation.

The Drug Metabolism and Pharmacokinetics (DMPK) group at Gilead Sciences is seeking a candidate for the position of Senior Research Scientist with the primary responsibility to serve as a modeling and simulations DMPK scientist supporting biologics discovery and development project teams.

Specific Responsibilities:

The primary responsibility of this Biologics DMPK Senior Scientist position is the design, execution and interpretation of the quantitative pharmacology strategies informing the development of large molecule drug candidates. The scientist would also serve as a DMPK project representative supporting biologics discovery and clinical development programs including business development opportunities.

Essential Duties and Job Responsibilities:

  • Serve on project teams at various stages of discovery and development as a subject matter expert for DMPK Biologics, providing PK or PK/PD input to the design of nonclinical PK, toxicology, or pharmacology studies.

  • As a DMPK project representative a candidate will lead the DMPK strategy for programs at various stages of drug discovery/development in collaboration with an inter-disciplinary team.

  • Perform hands-on devising, implementation and interpretation of quantitative strategies to inform the design and translation of the PK-PD properties of biologic therapeutics from early stages of preclinical development to the design of first in human studies.

Knowledge, Experience and Skills:

  • Requires a highly motivated individual with a PhD, or a MS degree with 6+ years, or a BS degree with 8+ years in Pharmaceutical Sciences, Chemical or Biomedical Engineering or related field with focus on mechanistic PK-PD modeling and/ or quantitative pharmacology analyses and/or industry experience in large molecule/biologics discovery and development.

  • Candidates must have solid grasp of the fundamentals of Pharmacokinetics and Pharmacodynamics principles and demonstrated experience using mathematical modeling tools to capture the behavior of in vitro/in vivo pharmacological systems and leveraging these to answer scientific inquiries.

  • Hands-on experience in the implementation of PK and PK-PD modeling analysis using software systems such as Phoenix/WinNonlin, ADAPT, MATLAB/Simbiology, R, Monolix or similar is required.

  • Applicant must demonstrate excellent verbal and technical communication, independent scientific thinking, with the ability to interpret results, determine next steps and present data to project teams and senior management.

The salary range for this position is: $165,580.00 - $214,280.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

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For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.