Translational and Computational Pathologist

GlaxoSmithKline

GlaxoSmithKline

Upper Providence Township, PA, USA
Posted on Saturday, February 10, 2024

Are you excited by an opportunity to be part of the evolving landscape of digital pathology? Would you like to break the mold of conventional pathology thinking? If so, this role may be for you!

As a translational and computational pathologist scientist, you will join a team of experienced pathologists, immunologists, PhD, PharmD, and MS-trained and accomplished scientists within Precision Medicine organization of Clinical Development at GSK.

You will work as part of the broader drug discovery, research, clinical development, artificial intelligence and machine learning (AI/ML) organizations with the goal of bringing new medicines urgently to patients in need. The Precision Medicine organization drives selection, stratification, and exploratory strategies in haematological & solid tumor, respiratory, immunologic, infectious diseases, and vaccines medicines development and trials. Within Oncology, research and early development delivers strategically via diverse asset classes and mechanisms.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

  • Guide, hone, and refine priority oncology, respiratory, immunology and infectious diseases clinical development strategies and provide technical input to clinical study designs across GSK.

  • Enable rigorous biomarker & diagnostics plans with biomarker scientists, companion diagnostic scientific leads, and research unit experts in study selection and stratification needs as well as collaborating with the translational research organization.

  • Clinical biomarkers assay and companion diagnostics development, oversight, and strategy, internally and externally with CRO’s and partners.

  • Lead and build high-innovation clinical-grade bioassays to fulfill study program needs.

  • Drive work with a First-in-Industry artificial intelligence and machine learning (AI/ML) organization with embedded computer scientists to build state of the art computer vision digital pathology quantitative tools to generate high density data to support first-time-in-human studies through late development (Ph2/3+).

  • Review protocols in writing, amendment, and revision with active participation in study governance to ensure we prepare the best studies to bring our medicines to patients efficiently and successfully.

  • As a subject matter expert, you will support companion diagnostics across the business, have opportunities to interface with regulatory authorities, prepare submission documentation within your scope and guide responses to health authority inquiries.

  • Support clinical trials advisory boards on pathology-related endpoints, seek input from key opinion leaders and deliver concise recommendations to study teams.

  • External KOL and clinical trial site interfacing as well as external technology, diagnostic vendor, and business development oversight and strategy.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • MD or DO earned degrees from an accredited training program and board certification required (or local equivalent i.e.,. MBBS, MBChB).

  • Residency Anatomic Pathology (AP) or combined Anatomic Pathology/Clinical Pathology (AP/CP) training and American Board of Pathology (ABP) board certification (or equivalent e.g. GMC).

  • Surgical Pathology subspecialty training (i.e.,, gastrointestinal, gynaecologic, breast, head and neck, genitourinary, or hematopathology) and board-certification.

  • Proficiency in laboratory medicine (i.e. molecular genetic pathology, flow cytometry) with assay development and validation oversite (internal and external), clinical interpretation, and regulatory aspects. Quality is a must and interfacing with quality teams across the organization is key to our success.

  • Understanding of pathophysiology of, and clinical practice for, human diseases.

  • 5+ years relevant clinical work experience (includes medical education in hospital, outpatient clinic and other medical environments including training).

  • 2+ years additional post graduate clinical work experience.

  • Experience in diagnostic pathology and laboratory medicine skills who demonstrate an ability to interpret pathology data in the context of a deep understanding of molecular and cellular biology. We expect candidate to formulate testable hypotheses.

  • Experience with image analysis tools (i.e., Halo, Visiopharm) and whole slide image (WSI) review, management, and desire to excel in computational pathology.

  • Data & science experience: Basic statistics, quality assurance, and experimental controls.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Master’s level degree (i.e. MS, MEng, MPH) and/or Ph.D. in a related field with bench wet-lab experience, in addition to the MD or DO degree (or foreign equivalent), is desirable as is a clear demonstration of high-quality scholarly inquiry of biomedical research.

  • Pharmaceutical industry experience in translational biomarkers, clinical development, field, or discovery is preferred but not required.

  • Immunohistochemistry, molecular/genomics/NGS and flow cytometry assay validation, review, creation, optimization, and data reporting.

  • Track record of regulatory engagements.

  • Clinical trials matrix team experience.

  • Track record of companion diagnostics development in IHC, molecular genetic pathology, flow or other area including, verification, validation, external laboratory oversite, alliance management.

  • Additional board certification in other pathology subspecialties (i.e., molecular genetic pathology, neuropathology).

  • Experience in one or more of these areas: digital pathology, image analysis, data science, computer programming, and related investigative methods, immunopathology or genetic basis of disease, biomarkers, organ or system-based pathobiology expertise, drug discovery, and drug development.

  • Experience in clinical and research laboratory setup, leadership, public speaking, education of histo-technologists, trainees, allied health professionals, inspection and quality monitoring in anatomic pathology as demonstrated by CAP^ inspector and/or lead inspector trainings.

  • Clinical trials support, protocol and study documentation review/authorship, contract research organization interfacing, multinational matrix influencing skills.

  • Ability to handle several projects at any given time, to work successfully and collaboratively in teams and to communicate clearly, both verbally and in writing, to a variety of audiences.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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