System Modelling and Simulations Expert



Multiple locations
Posted on Saturday, February 10, 2024

We are looking for a Systems Modelling & Simulations Expert to join our team in the UK.

As experts in the field our team implements Process Systems Engineering, Modelling and Simulations approaches on medicines in development to increase understanding and greatly reduce labor, materials and time required to identify commercial manufacturing processes. The team provides support to the entire GSK portfolio across on Small Molecules Drug Substances and Drug Products, Biopharmaceuticals and Vaccines.

The Systems Modelling & Simulation Experts also support upskilling project team members to expand the use of models and simulations, as well as work with internal and external technical experts to develop and maintain core simulation software platforms. We also champion the integration of new ways of working into existing pharmaceutical “Quality by Design” workflows (eg; Process Design, Control Strategy Identification, Risk Assessment), regulatory filing strategies, and product life-cycle support.

Key Responsibilities (include):

  • Develop and deploy Process Systems Engineering, Modelling and Simulations approaches to the diverse GSK portfolio across small Molecules Drug Substance, Drug Product, Biopharmaceuticals and Vaccines.

  • Pioneer and develop novel approaches including but not limited to mechanistic modelling, systems modelling, multiscale modelling (e.g. Computational Fluido Dynamics).

  • Translate mathematical models to computer models using software platforms (e.g. gPROMS, DynoChem, Ansys, COMSOL) or by developing custom solutions (e.g. in Matlab, Python, etc.)

  • Use engineering, chemical, biological or materials science knowledge to postulate mechanisms for physiochemical and biological processes and develop or modify existing mathematical models to describe those mechanisms.

  • Package models into web applications to ensure accessibility and support to the development of colleagues in engineering, chemistry and formulation science on the use of modelling tools.

  • Develop and maintain key modeling platforms (e.g. gPROMS for systems modelling, Matlab for web applications).

  • Direct experimentation and the analysis required to develop models and assess their credibility (e.g. parameter estimation).

  • Stay current with new modeling techniques through external publications and conferences and academic and pre-competitive collaborations.

  • Leverage external expertise and funding through alliances and academic collaborations to identify, develop and internalize novel modelling approaches for process development.

  • As part of a matrix process development team, use Process Systems Engineering, Modeling and Simulations to efficiently deliver team priorities, including but not limited to Process Design, quantitative Risk Assessment, Identification of Critical Process Parameters / Design Space and implementation of advanced process controls.

  • Provide and coordinate training and real-time support to expand the use of modeling (simulations) across the Development and Manufacturing environments.

  • Work closely with the Subject Matter Experts in Pharmaceutical Quality by Design, regulatory and Information Technology to integrate process modelling into process development routine ways of working and drive cultural changes in the adoption of Digital, Data and Analytics across the organization.

  • Advocate and comply with Good Manufacturing Practice (GMP) and Data Integrity requirements for recording experiments and associated data and authoring technical reports including scientific peer review and data checking.

  • Provide input to budgets, recommend capital purchases of software supporting modeling.

  • Comply with requirements on Safety, Quality for the Patient and GSK policies and procedures (sites and department).

Location: We are flexible (to some extent) on location. Successful applicants can work from our Ware, Stevenage or Head-Office (London) locations.

About You:

We are open-minded about your level of experience (we encourage recent graduates as well as more experienced applicants to apply), but we are seeking people who are passionate about simulation and modelling solutions.

CLOSING DATE for application: Monday 26th of February 2024 (COB).

Basic Qualifications:

  • Vocational / higher level qualification in a relevant discipline (eg; MSc, PhD, etc) with an emphasis on development and implementation of process models and simulations.

  • Ability to translate mathematical models into computer programs (eg; using Matlab, Python, gPROMS or similar software tools).

Preferred Qualifications:

  • Experience with engineering software (eg; gPROMS, Dynochem, Ansys, COMSOL) and with programming languages (eg; Python, Matlab).


GSK offers a range of benefits to its employees, which include, but are not limited to:

  • Competitive base Salary

  • Annual bonus based on company performance

  • Opportunities to partake in on-the-job training courses

  • Opportunities for support for professional development and chartership (accreditations and professional bodies)

  • Access to healthcare and wellbeing programmes

  • Employee recognition programmes

If you would like to learn more about our company wide benefits and life at GSK we would suggest looking at our webpage Life at GSK | GSK.

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive .

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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