Scientific Director, DMPK Modelling



Multiple locations
Posted on Sunday, May 19, 2024

GSK is looking for a dynamic Scientific Director to join their DMPK modeling group. As an individual contributor, the scientific director will have the opportunity to lead the development and implementation of MIDD (QSP, PKPD and PBPK) strategies within the DMPK modeling group. Along with other DMPK team members, they will collaborate across various cross-functional teams including biology, chemistry, clinical pharmacology, toxicology and formulations, contributing to the prediction of human efficacious dose across lead optimization and candidate nomination and contribute to internal dossiers & regulatory responses for small/large molecules and novel modalities.

Responsibilities: This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following.

  • Work with global DMPK Leadership Team, wider modelling group and data sciences to deliver harmonised, cutting-edge modeling strategies, driving efficiency through software selection, App development and visualisations.

  • Support DMPK project representatives to identify and apply optimal modeling strategies and tools to support projects across discovery phases.

  • Independently build, validate, and apply models to support mechanistic understanding of absorption and systemic exposure potential for new chemical entities, biologics and new modalities.

  • Drive model informed drug discovery (MIDD) by providing valuable input into various DMPK assays, PKPD study design and clinical study protocols based on modeling outputs or requirements.

  • Utilise insights from relevant clinical data, through the application of modelling expertise to help direct preclinical drug discovery.

  • Provide valuable training and mentoring to support the development of existing and new staff together with the education of business partners.

  • Present modeling strategies and outputs in internal department meetings as well as external /international conferences.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • Advanced degree (PhD) in a relevant scientific discipline (Maths, pharmacology, biochemistry or other DMPK related science)

  • 5+ years’ work experience in related field or area of science

  • Experience in developing & implementing MIDD strategies across drug discovery and development phases.

  • Experience working with physicochemical properties and how it relates to drug disposition.

  • Experience in approaches and capabilities to conduct human PK and efficacious dose prediction.

  • Experience with DMPK scientific applications across drug discovery and development, including translational understanding of PK and PKPD.

  • Experience with peer-reviewed publication, public speaking / presentation

  • Track record of consortia engagement (e.g., IQ, ISSX, Acop)

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Excellent verbal communication skills.

  • Strong influencing skills across multiple formats including face to face and virtual project team environments.

  • The ability to work independently with excellent organizational and interpersonal skills

  • Demonstrated success in leading cross-functional small and large molecule drug discovery teams.


Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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