Investigator, Medicinal Chemistry



Upper Providence Township, PA, USA
Posted on Wednesday, June 5, 2024

We are currently looking for highly motivated organic chemists to join our Medicinal Chemistry team (including but not limited to: discovery, high-throughput, and modality agnostic chemistry) at our Upper Providence, PA site. Our department partners with program teams across GSK’s research units to deliver high quality small molecules, from hit generation through late-stage lead optimization to address increasingly complex disease areas.

The purpose of the role is to provide a high level of scientific and technical contributions to projects within the Medicinal Chemistry portfolio (including but not limited to: small molecules, PROTACs, degraders, oligonucleotides, covalents, and antibody-drug conjugates) with a primary responsibility of driving efficiencies applying novel synthetic methods and techniques to design, synthesize, and purify candidate molecules.

The successful applicant will become fluent in all areas of medicinal chemistry while working as part of a highly productive team to design and synthesize developable drug molecules. The role involves, to differing degrees, medicinal chemistry, data analytics, designing compounds to test medicinal chemistry hypotheses, synthetic organic chemistry to support both medicinal chemistry and/or candidate selection and championing technological advances.

The successful candidate will work collaboratively across teams of synthetic chemists, analytical chemists, engineers, and data analytics experts to help invent these new processes and chemistries to solve impactful problems that will accelerate delivery of important medicinal advancements to patients. Successful candidates must be able to think creatively, champion the needs of the organization and work collaboratively within a team environment.

When submitting your CV/Resume please also include a Research Statement.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

  • The individual will be fully dedicated to executing on organic chemistry and synthesis within the Med Chem organization - expected to design, synthesize, purify, and characterize drug candidates.
  • Demonstrating scale-up capabilities and/or deep expertise in modern synthetic technologies and/or methodologies.
  • The individual applies the principles of medicinal chemistry, including high throughput experimentation and modern in silico design approaches, to accelerate program objectives and drug discovery.
  • Job holders can react to emerging data and to independently propose a modification of plans for the area of science they are responsible for
  • Communication of key results and data to stakeholders and senior managements when necessary.
  • Be an excellent team player within a matrixed organization, working cross-functionally across other departments including but not limited to engineering automation, analytical chemistry, process chemistry, sample management, and molecular biology/assay sciences.
  • Job holders support patents and publications write-ups when appropriate

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • Ph.D. in Organic Chemistry, Synthetic Methodology Development, Medicinal Chemistry, or related discipline
  • Experience in synthetic chemistry; the application of new synthetic methodology and execution of multi-step syntheses.
  • First author peer-reviewed publications, patents, or presentations

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Postdoctoral experience and/or 1-5+ years industrial experience
  • Expertise in both synthetic methodology development and total synthesis
  • High-throughput experimentation experience
  • Data analytics and cheminformatics experience
  • Track record of working effectively in a team environment
  • An ability to work with other scientific disciplines to drive results.
  • Proactive and self-motivated
  • Strong interpersonal skills
  • Highly organized with strong attention to detail and a focus on quality results
  • Excellent written and oral communication skills
  • High learning agility and curiosity to learn and adopt new technologies.
  • High learning agility and curiosity to learn and adopt new technologies.
  • Self-aware; seeks ways to improve personal and scientific skills.


Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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