Job Description

Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.

The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist to join our innovative team. This position will play a crucial role in the supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company's clinical therapeutic pipeline.

The individual will have the following responsibilities:

• Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company's therapeutics.

• Collaborate in the development and analytic validation of digital pathology algorithms.

• Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials.

• Establish new histopathology-based assays in the laboratory as part of a team.

• Provide subject matter of expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders.

Position Qualifications:

Education Minimum Requirement:

• Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology.

Required Experience and Skills:

• Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations.

• Experience ensuring compliance of a clinical laboratory with regulatory standards.

• Experience with the development and analytic validation of digital pathology algorithms.

• Excellent oral and written skills with a proven record of scientific contributions to the scientific community.

• Demonstrated ability to lead and manage projects in a fast-paced environment.

• Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators.

• Eplinary teams.

• Strong understanding of disease processes and pathways relevant to our company's therapeutics.

Preferred Experience and Skills:

• Experience working in the pharmaceutical industry.

• Broad knowledge of the drug development process and translational medicine.

• Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.

• Experience with multiplex tissue-based spatial profiling assays (i.e., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry).

• Familiarity with image acquisition platforms (i.e., Leica Aperio, Hamamatsu, Pannoramic).

• Proficiency in commercial or open-source image analysis software packages (i.e., Visiopharm, HALO, QuPath).

• Knowledge of using statistical software packages (i.e., Prism, SPSS).

• Understanding of regulated clinical bioanalysis.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

$153,800.00 - $242,200.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

04/30/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R341001