Principal Engineer, Imaging Systems

Leica Microsystems

Leica Microsystems

Vista, CA, USA
Posted on Tuesday, February 27, 2024

Leica Biosystems’ mission of “Advancing Cancer Diagnostics, Improving Lives” is at the heart of our corporate culture. We’re a global leader in cancer diagnostics with the most comprehensive portfolio from biopsy to diagnosis. Our easy-to-use and consistently reliable offerings help improve workflow efficiency and diagnostic confidence.

Our associates know that every moment matters when it comes to cancer diagnostics. When you come to work, you’re helping develop solutions that enable accurate diagnoses to turn anxiety into answers. Join our diverse, global team of talented people, and be inspired to grow every day. Leica Biosystems is proud to work alongside a community of six fellow Diagnostics Companies at Danaher. Together, we’re working at the pace of change to improve patient lives with diagnostic tools that address the world’s biggest health challenges.

The Principal Engineer, Imaging Systems is a hands-on role and will be providing technical expertise and solutions for complex technical problems to the hardware & software engineering teams (which may include optical, mechanical, electronic mechatronic disciplines, and software). You will be a technical leader within a team that is designing world-class digital scanners for the industry.

Location: This position is eligible for a hybrid work arrangement which includes a combination of working onsite in the Vista, CA office and from your home.

Major Responsibilities:

  • Develop image analysis solutions to reliably detect and quantify imaging system artifacts such as digital noise, imperfect focusing, system gain drifts, etc.

  • Use technical experience to develop complex opto-mechanical and electro-mechanical microscope imaging devices and be recognized as a subject matter expert within the business.

  • Deliver robust and high-quality engineering solutions that are compliant with all applicable business and regulatory requirements.

  • Develop digital scanner architecture and contribute to the quality of the hardware & software engineering groups’ deliverables.

  • Act as hands-on and remote escalation for manufacturing and field issues relating to focusing, color reproducibility, and other imaging system phenomena.


  • Bachelor in engineering, physics, optics, or elated major, or equivalent experience can be considered.

  • Qualified Engineer with minimum 8 years’ relevant experience in developing and delivering complex opto-mechanical and/or electro-optical devices.

  • Experience with ISO13485 or FDA QSR 820.

  • Ability to make recommendations and decisions by balancing technical risks and business needs.

  • Experience with a variety of manufacturing methods and working with suppliers.

Preferred Experience & Skills

  • Interest in histology, pathology, or related fields

  • Experience programing during product development and for data analysis is highly desired

  • Demonstrated track record of delivering solutions to difficult problems within microscope or other imaging systems.

This position will be an onsite role in Vista, CA . Relocation assistance is also provided.

The salary range for this role is $145K-$185K. This is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range. This range may be modified in the future.

This job is also eligible for bonus/incentive pay.

We offer comprehensive package of benefits including paid time off, medical/dental/vision insurance and 401(k) to eligible employees.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law.


At Danaher we bring together science, technology and operational capabilities to accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life. Our global teams are pioneering what’s next across Life Sciences, Diagnostics, Biotechnology and beyond. For more information, visit

Danaher Corporation and all Danaher Companies are committed to equal opportunity regardless of race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law. We value diversity and the existence of similarities and differences, both visible and not, found in our workforce, workplace and throughout the markets we serve. Our associates, customers and shareholders contribute unique and different perspectives as a result of these diverse attributes.

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We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform crucial job functions, and to receive other benefits and privileges of employment. Please contact us at to request accommodation.