Senior Research Analyst (Flow Cytometry) - LGC National Laboratories

LGC Clinical Diagnostics

LGC Clinical Diagnostics

IT
United Kingdom
Posted on Thursday, July 11, 2024

Company Description

ABOUT LGC NATIONAL LABORATORIES:

LGC’s National Laboratories deliver a range of expert science functions and services in partnership with the UK Government, business, healthcare, and academia. We manage and operate several national laboratories on behalf of government agencies, such as the UK National Measurement Laboratory (NML), MHRA Laboratories Team and National Reference Laboratories, as well as hosting the unique function of the ‘Government Chemist’.

As home to many world-leading scientists, LGC’s National Laboratories provide a wide range of expert analytical science services and subject matter expertise to a broad spectrum of customers, stakeholders, and global forums. In addition, we undertake contract research and development projects for a range of customers in both the public and private sectors. Our work addresses fundamental and emerging measurement challenges, helping to foster innovation and promoting productivity and economic growth.

In regards to the location of the role, you will be based in NML Cell Metrology Laboratory in Leeds.

Job Description

Job Description

There is an exciting opportunity to join the Cell Metrology team within the National Measurement Laboratory at LGC, based on Nexus, Leeds!. We are looking for an early career post-graduate cell biologist with flow cytometry experience who can assist in developing and improving quantitative methods for cell-based measurements, feeding into international standardisation initiatives. Current research efforts are focused on optimising single cell measurements through the use of bio-imaging techniques such as flow cytometry and microscopy to identify key cell critical quality attributes.

This is a great opportunity for an enthusiastic scientist adept in FACS analysis to join a small team addressing fundamental and emerging cell measurement challenges!

This individual will primarily be involved in delivering government funded cell metrology research and commercial projects primarily using flow cytometry and cell sorting but also support confocal microscopy and cell culture for multiple projects.

Training as appropriate will be provided on traceability of measurements to the System of International Units and on the instruments required for the delivery of the projects. This is a good opportunity for candidates looking to progress their career in cell-based measurements with a potential to lead future projects.

Key Responsibilities

  1. Independent day-to-day planning and delivery of work.
  2. Responsible for conducting analytical work including method development and validation, biological specimen preparation, data acquisition and subsequent data analysis for flow cytometry and cell sorting.
  3. Create working instructions and maintain laboratory notebooks.
  4. Contribute to scientific writing to produce publications and client reporting and represent the team in internal and external events.
  5. Contribute to the maintenance of quality, health, and safety records, adhering to ISO9001 quality management system.
  6. Participate in maintaining cleaning procedures, ordering consumables and general upkeep of the laboratory.
  7. Responsible for routine maintenance to determine system performance, service contracts, operation and troubleshooting of flow cytometry and cell sorting instruments.

Qualifications

Qualifications

Knowledge, Experience and Technical Skills Required

The successful candidate will be a PhD degree or equivalent experience or MRES holder with relevant industrial experience in cell culture and flow cytometry practices. This early career post-graduate researcher should have experience crafting and performing multi-parametric flow cytometry panels in a variety of samples.

The candidate will be able to demonstrate the following attributes:

Essential:

  • Proficient in running, troubleshooting flow cytometry and cell sorting instrumentation.
  • Extensive cell culture experience using adherent and suspension mammalian cell lines and primary cells.
  • Good understanding of cell characterisation and enumeration techniques.
  • Proficient in method development and validation skills with a keen interest in improving methodology/practices.
  • High level of organisation regarding sample preparation, data collection and data analysis.
  • Ability to work effectively in a team environment and work collaboratively in cross-functional teams.
  • Willingness to learn new techniques and integrate into existing processes

Desirable:

  • Proficient in the use of FCSExpress, FlowJo, CytExpert or Attune software for flow cytometry data analysis.
  • Prior experience of using the Attune, Cytoflex and BD FACS melody instrumentation.
  • Experience in using cell imaging techniques such as brightfield, widefield and confocal microscopy.
  • Prior experience of producing peer review publications and presenting (poster and presentation) work internally or externally.

Additional Information

ABOUT LGC:

LGC is a leading, global life science tools company, providing mission-critical components and solutions into high-growth application areas across the human healthcare and applied market segments. Its high-quality product portfolio is comprised of mission-critical tools for genomic analysis and for quality assurance applications, which are typically embedded and recurring within our customers’ products and workflows and are valued for their performance, quality, and range.

OUR VALUES

  • PASSION
  • CURIOSITY
  • INTEGRITY
  • BRILLIANCE
  • RESPECT

EQUAL OPPORTUNITIES

LGC strongly believes that every job applicant and employee should be valued for their individual talents regardless of age, disability, race, color, ethnic or national origin, sex, sexual orientation, gender reassignment, marital or civil partnership, pregnancy or maternity, religion, or belief. Short listing, interviewing and selection will always be carried out without regard to gender, sexual orientation, marital status, color, race, nationality, ethnic or national origins, religion or belief, age, or trade union membership.

For more information about LGC, please visit our website www.lgcgroup.com

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