Postdoctoral Fellowship - Applied Molecular Biology Division

New England Biolabs

New England Biolabs

United States
Posted on Friday, February 9, 2024

We are seeking a talented, highly motivated researcher to join the Applied Molecular Biology Division at New England Biolabs (NEB) as a postdoctoral fellow. The successful candidate will primarily focus on biochemical and structural characterizations of DNA deaminases as well as enzyme engineering to improve the enzyme characteristics and applications.

Primary responsibilities:

  • Express and purify DNA deaminases and determine their substrate specificity.

  • Collaborate with external labs to investigate the structures of DNA deaminases with bound substrates and elucidate the substrate specificity mechanisms of DNA deaminases.

  • Engineer DNA deaminases to improve their substrate selectivity or change their substrate specificity through rational design or high throughput engineering.

  • Apply DNA deaminases in next-generation sequencing (NGS) to detect epigenetic modifications.

  • Explore DNA deaminases in base-editing applications.

  • Effectively communicate the discoveries to the scientific community through presentations and peer-reviewed publications.

Required Qualifications and Experience:

  • Ph.D. in Biochemistry, Molecular Biology, Chemical Biology, or related field.

  • Advanced skill level in molecular biology and protein biochemistry techniques.

  • Strong multitasking ability.

  • Excellent verbal and written communication skills.

  • Proven ability to work independently and in collaborative team environments.

Preferred Qualifications and Experience:

  • Hands-on experience with protein expression, purification (IMAC, IEX, SEC), and biochemical or biophysical characterizations.

  • Experience with structural biology (x-ray crystallography or structural modeling).

  • Experience with protein engineering.

  • Experience with next-generation sequencing (NGS) and epigenetic modification detection is a plus.

This position offers exciting opportunities for research training in an industrial setting, collaboration with academic institutions, publishing in peer-reviewed journals, and participation in meetings and conferences.

EEO Statement

New England Biolabs is committed to fostering a diverse and inclusive community; as an EEO/AA employer, New England Biolabs considers applicants for employment without regard to, and does not discriminate on the basis of, race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability. More in-depth details of EEO are available here.

Information regarding New England Biolabs commitment to Diversity, Equity and Inclusion can be found here.

New England Biolabs is a participating employer in the Employment Verification (E-Verify) program.

OFCCP’s pay transparency policy can be found on OFCCP’s website at www.dol.gov/ofccp

If you need an accommodation for any part of the employment process because of a medical condition or disability, please send an email to hr@neb.com or call 978-927-5054 to let us know the nature of your request.