Location: London, UK

Reporting to: Director, Translational Research

Job summary

Orchard Therapeutics is a pioneering company in the field of cell and gene therapy where the Translational Research Department develops novel and innovative applications of Orchard’s platform of hematopoietic stem cell gene therapy. This role will be based in West London in our Hammersmith Research facility within our global headquarters.

The Senior Scientist in Neurology, will perform experimental laboratory duties related to the design and development of preclinical research models to evaluate the feasibility and the efficacy of cell and gene therapies in neurodegenerative disease models and/or other neuroscience research programs under development by the Translational Research Team. The role will specifically involve performing preclinical research to develop a variety of analytical techniques, and to develop and implement the use of innovative in vitro cell culture models and ex vivo models of disease, to drive the discovery and validation of therapeutic targets addressable by gene therapy.

The Senior Scientist will work closely with the Research Director and other scientists to design and plan experiments, establish and run experimental studies, ensure compliance in documentation, and be responsible for analysis, interpretation, presentation and reporting of experimental studies.

Key Elements and Responsibilities

· Contribute towards the design, planning and conduct of experimental pre-clinical research models and studies for assigned research programs.

· Perform in vitro and ex vivo experiments in the laboratory, including data analysis, interpretation and presentation.

· Oversee the preparation, review and completion of study reports and protocol SOPs.

· Work with other scientists to develop new ideas and solutions to research questions.

· Contribute to the overall activities of the research team and department as required, including laboratory duties, attendance and participation in group and department meetings.