Sr. Scientist I - Assay Development, Biology

RayzeBio

RayzeBio

San Diego, CA, USA · San Diego, CA, USA · California, USA
Posted on Friday, May 17, 2024

Job Title: Sr. Scientist, Biology

Location: San Diego

NH#: 88

Backgroun

dRayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals

.

Job Descripti

onThe role offers an opportunity to advance a pipeline of novel Radiopharmaceutical therapies from target selection through candidate nomination. The ideal candidate will have excellent communication and presentation skills and will be a highly motivated biologist with a broad technical skill set to support design and execution of experiments in a drug discovery setting. The role will have an opportunity to work on multiple projects ranging from target selection through candidate nomination stages and can be expected to lead early-stage projects in an interdisciplinary setting. The role is technical and will need a person who enjoys leading from the bench with strong experimental and data analysis skills and a comfort level in working under tight timelines. The role requires an ability and willingness to work with radioactive isotope

s.

Job Responsibilit

iesEssential duties and responsibilities include the following. Other duties may be assign

ed.• Conceptualize and execute in vitro assays which contribute to answering key biological questions on project and support the screening, characterization, and lead-identification of novel RPT agen

ts.• Utilize a deep understanding of cancer biology and oncology drug development to support the target selection and initiation of new TRP projec

ts.• Work in close collaboration with interdisciplinary team members to provide needed biology support to guide programs through lead identification/optimization phas

es.• Support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experimen

ts.• Work under the guidance of clinical, translational leads to help implement the translational biology plan to support the clinical development strate

gy.• Help generate, review technical reports in support of regulatory submissions and support the publication/presentation plans with active contributio

ns.• Identify external partners, KOLs, outside expertise that will help advance the pipeli

ne.• Supervise the work of junior scientists and ensure experimental rigor and high quali

ty.

Education and Experi

ence• PhD in cancer biology, cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development is ideal. Exceptional BS/MS candidates with strong track record of scientific accomplishments in industrial settings will also be conside

red.• PhD 2 + years or BS with 7+ years of experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilit

ies.• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desira

ble.

Skills and Qualifica

tions• Expertise with invitro, cell-based assay development and optimization and proficiency with Cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, single-cell cloning, immunohistochemistry and related proto

cols.• Ability to effectively partner with chemistry/DMPK, imaging and in vivo teams and ability to effectively interpret data and plan experiments accordi

ngly.• Strong technical problem-solving skills and a basic familiarity with ADME/PK concepts, drug design and the use of appropriate in vivo oncology models is crit

ical.• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environ

ment.• Ability to work with radioisotopes with strict adherence to radiation safety proto

cols.• Demonstrated ability to supervise and effectively guide the work of junior scientists and demonstrated ability of productivity in an industrial drug discovery set

ting.