Global Translational Lead, Hematology-Oncology

Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited

Boston, MA, USA
Posted on Dec 17, 2024

Global Translational Lead, Hematology-Oncology

Boston, Massachusetts
  • Job Level: Senior
  • Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0140511 Date posted 12/16/2024 Location Boston, Massachusetts

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Global Translational Lead in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES:

The Oncology Global Translational Lead (GTL) role is an exciting opportunity within the growing Precision and Translational Medicine (PTM) function in the Oncology Therapeutic Area Unit (OTAU) at Takeda. This is a highly visible, strategic, and matrixed role that leads, and is accountable for the Translational Subteam of the Global Program Team (GPT). The GTL develops and drives translational impact from strategy development through insight generation. GTLs are strong scientific leaders, with extensive drug development experience combined with exceptionally strong matrix leadership and communication skills. This role will partner closely with key functions across Takeda Oncology including Clinical, Drug Discovery, Clinical Pharmacology, Companion Diagnostics, Global Regulatory Affairs, Biomarker Sciences and Technologies, Global Medical Affairs, and Commercial. We are currently looking for a GTL to develop and deliver program level translational strategy for late clinical oncology development programs in the hematology oncology space (e.g. myelodysplastic syndromes and myelofibrosis). This role reports to the Head of Oncology Precision and Translational Medicine.

ACCOUNTABILITIES:

  • Develop and deliver overarching program level translational strategy as a core member of the Global Program Team (GPT). Represent translational medicine at internal governance meetings.
  • Ensure broader program level scientific translational objectives and plans are developed to advance the program and help better position the program for success
  • Ensure that robust translational hypotheses are assessed, including evaluation of predictive and patient segmentation biomarkers, development of indication selection and expansion strategies, and contribute to publication strategy and commercial differentiation efforts.
  • Gain internal and external stakeholder input and alignment on the program level translational strategy.
  • Communicate translational status updates for key deliverables to OTAU and other Takeda leaders as needed.
  • Identify translational issues and resources needs, develop solutions, and escalate to the broader organization as needed for resolution
  • Lead the translational medicine sub-team of the GPT comprised of key internal drug development functions and partners (clinical, clinical biomarkers, biomarker technologies, bioinformatics, statistics, drug discovery, diagnostics, project management) to develop and deliver program and study level translational strategy
  • Accountable for clinical biomarker plans and work closely with and also mentor study-focused Clinical Biomarker Leads who support biomarker strategy, data delivery, analysis and interpretation in partnership with the GTL. Review and provide input into clinical protocols, informed consent forms, IBs, clinical study reports and other related documents as needed
  • Partner with Medical Affairs to develop and integrate translational data into program level publication, investigator sponsored research, and communication strategies
  • Partner with Commercial to integrate translational elements into the target product profile and launch plans
  • Partner with Regulatory Affairs and ensure appropriate biomarker elements are incorporated with rigor into BLA and NDA filings with health authorities, works closely with the program team to respond to health authority questions or requests for information; may participate in health authority meetings as needed

EDUCATION AND EXPERIENCE

  • PhD and/or MD in cancer biology, immunology, genetics, pathology, or related field with 8+ years of experience in pharmaceutical or biotech R&D. MS or BS with 12+ years of research and development experience with progressive levels of team leadership also considered.
  • Preference for those with 5+ years experience as a Translational lead for clinical programs. Experience with Ph2/3 or registrational programs desired.
  • Oncology and/or immunology experience with demonstrated focus on hematology oncology malignancies. Strong knowledge of hematopoiesis and experience in MDS/MPN/MF preferred.
  • Experience developing and delivering translational and biomarker strategies for late stage (Ph2/3 and registrational) clinical programs
  • Experience developing and testing translational hypotheses, interpreting biomarker data in clinical studies
  • Excellent understanding of drug development, regulatory processes and clinical development
  • Strong leadership abilities and proven ability to lead a team within a matrix organization as well as able to work independently and be proactive.

SKILLS

  • Excellent communication (written and oral) skills
  • Excellent strategic, interpersonal, influence, and negotiating skills
  • Demonstrated ability to work effectively across functions, projects, and time zones
  • Ability to assemble and motivate cross functional stakeholders and drive results
  • Capable of proactively predicting issues and solving problems with agility
  • Ability to drive decision-making within a multi-disciplinary, multi-regional, matrix teams
  • Ability to drive multiple priorities forward simultaneously
  • Ability to lead/work successfully in hybrid virtual team setting as team members may be located in multiple buildings/cities
  • Strong scientific and research skills to be able to review/analyze/interpret internal and external data (translational, biomarker and clinical) and to compile insights on competitive landscape and understand potential impact on evolving program strategies

TRAVEL REQUIREMENTS:

  • Ability to drive to or travel to conferences, partner meetings, including overnight trips. Some international travel may be required
  • Requires approximately 10 - 15% travel

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law

This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy.

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Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

169,400.00 - 266,200.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

  • Design and carry out experiments

  • Manage multiple projects

  • Document data

  • Mentor other scientists

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

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About our location

Boston, Massachusetts


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